SERCA2 rabbit pAb

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Background

This gene encodes one of the SERCA Ca (2+) -ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]

Description

This gene encodes one of the SERCA Ca (2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008],

Product Name Alternative

ATP2A2; ATP2B; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca (2+) -ATPase 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca (2+) ATPase

UniProt

P16615

Swiss Prot

P16615

Reactivity

Human; Mouse; Rat; Chicken

Immunogen

The antiserum was produced against synthesized peptide derived from the C-terminal region of human ATP2A2. AA range:841-890

Target

SERCA2

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

115kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

115kD

Fragment

IgG

Subcellular Location

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Sarcoplasmic reticulum membrane ; Multi-pass membrane protein .

Other Product Names

Gene ID (Human)

488

UniProtKB · P16615

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

AT2A2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P16615
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ATP2A2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: SERCA2, SR Ca(2+)-ATPase 2
EC number: 7.2.2.10
Processing: —
Secondary accessions: A6NDN7, B4DF05, P16614, Q86VJ2

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingCalciumMagnesiumMetal-bindingNucleotide-binding

Biological process

Calcium transportIon transportTransport

Disease

Disease variantEpilepsy

PTM

Disulfide bondNitrationPhosphoprotein

Cellular component

Endoplasmic reticulumMembraneSarcoplasmic reticulum

Molecular function

Translocase

Domain

TransmembraneTransmembrane helix

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