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SDHB rabbit pAb

CAT: 0855-ES4180-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4180-02Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
Description
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008],
Product Name Alternative
SDHB; SDH; SDH1; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip
UniProt
P21912
Swiss Prot
P21912
Reactivity
Human; Mouse; Rat; Fish
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human SDHB. AA range:131-180
Target
SDHB
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
31kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
31kD
Fragment
IgG
Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Other Product Names
SDHB; SDH; SDH1; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip
Gene ID (Human)
6390

UniProtKB · P21912

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

SDHB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P21912
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SDHB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.3.5.1
Processing
Precursor
Secondary accessions
B2R545, Q0QEY7, Q9NQ12
Protein keywords

Ligand

2Fe-2S3Fe-4S4Fe-4SIronIron-sulfurMetal-binding

Technical term

3D-structureProteomics identificationReference proteome

PTM

Acetylation

Disease

Disease variantPrimary mitochondrial disease

Biological process

Electron transportHost-virus interactionTransportTricarboxylic acid cycle

Cellular component

MembraneMitochondrionMitochondrion inner membrane

Molecular function

Oxidoreductase

Domain

Transit peptide

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