Ob-R rabbit pAb

• Background :

  The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021) .[provided by RefSeq, Nov 2010]

• Description :

  The protein encoded by this gene belongs to the gp130 family of Cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID: 54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID: 9207021). [provided by RefSeq, Nov 2010],

• UniProt :

  P48357

• Swiss Prot :

  P48357

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from Leptin receptor at AA range: 791-840

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight :

  132kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  132kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane ; Single-pass type I membrane protein . Basolateral cell membrane .; [Isoform E]: Secreted .

• Other Product Names :

  LEPR; DB; OBR; Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD295

• Gene ID (Human) :

  3953