Ob-R (phospho Tyr1141) rabbit pAb

Ob-R (phospho Tyr1141) rabbit pAb

• Description: The protein encoded by this gene belongs to the gp130 family of Cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID: 54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID: 9207021). [provided by RefSeq, Nov 2010],
• Synonyms: LEPR; DB; OBR; Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD antigen CD295
• Gene ID: 3953
• UniProt: P48357
• Cellular Locus: Cell membrane ; Single-pass type I membrane protein. Basolateral cell membrane.; [Isoform E]: Secreted.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Ob-R (phospho Tyr1141)
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
• Molecular Weight: 132kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.