CXCR-3 rabbit pAb

CXCR-3 rabbit pAb

• Description: C-X-C motif chemokine receptor 3 (CXCR3) Homo sapiens This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID: 12782716). [provided by RefSeq, Jun 2011],
• Synonyms: CXCR3; GPR9; C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; CD183
• Gene ID: 2833
• UniProt: P49682
• Cellular Locus: [Isoform 1]: Cell membrane ; Multi-pass membrane protein.; [Isoform 2]: Cell membrane ; Multi-pass membrane protein.
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse, Pig, Chicken
• Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human CXCR3. AA range:161-210
• Clonality: Polyclonal
• Validated Applications: WB, IHC, IF, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
• Molecular Weight: 37kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.