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CD1D rabbit pAb

CAT: 0855-ES3969-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES3969-02Size:100 µL
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Background
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Description
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016],
Product Name Alternative
CD1D; Antigen-presenting glycoprotein CD1d; R3G1; CD1d
UniProt
P15813
Swiss Prot
P15813
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from Antigen-presenting glycoprotein CD1d at AA range: 161-210
Target
CD1D
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
37kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
37kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Basolateral cell membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein . Lysosome membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. .
Other Product Names
CD1D; Antigen-presenting glycoprotein CD1d; R3G1; CD1d
Gene ID (Human)
912

UniProtKB · P15813

Antigen-presenting glycoprotein CD1d

CD1D_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P15813
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD1D
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
D3DVD5, Q5W0J3, Q9UMM3, Q9Y5M4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneEndoplasmic reticulumEndosomeLysosomeMembrane

PTM

Disulfide bondGlycoprotein

Biological process

ImmunityInnate immunity

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

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