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DPYD rabbit pAb

CAT: 0855-ES3957-01Size: 50 µLDry Ice: NoHazardous: No
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Background
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Description
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009],
Product Name Alternative
DPYD; Dihydropyrimidine dehydrogenase [NADP (+) ]; DHPDHase; DPD; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase
UniProt
Q12882
Swiss Prot
Q12882
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human DPYD. AA range:351-400
Target
DPYD
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
120kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
120kD
Fragment
IgG
Subcellular Location
Cytoplasm.
Other Product Names
DPYD; Dihydropyrimidine dehydrogenase [NADP (+) ]; DHPDHase; DPD; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase
Gene ID (Human)
1806

UniProtKB · Q12882

Dihydropyrimidine dehydrogenase [NADP(+)]

DPYD_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q12882
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DPYD
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
DHPDHase, DPD
EC number
1.3.1.2
Processing
Precursor
Secondary accessions
A2RRQ2, A2RRQ3, A8K5A2, A8MWG9, B1AN21, E9PFN1, Q16694, Q16761, Q32NB0, Q96HL6, Q96TH1
Protein keywords

Ligand

4Fe-4SFADFlavoproteinFMNIronIron-sulfurMetal-bindingNADPNucleotide-binding

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

Cytoplasm

Technical term

Direct protein sequencingProteomics identificationReference proteome

Disease

Disease variant

Molecular function

Oxidoreductase

Domain

Repeat

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