RegisterLogin

MCM3 rabbit pAb

CAT: 0855-ES3947-01Size: 50 µLDry Ice: NoHazardous: No
CAT#: ES3947-01Size: 50 µL
Selected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Description
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012],
Product Name Alternative
MCM3; DNA replication licensing factor MCM3; DNA polymerase alpha holoenzyme-associated protein P1; P1-MCM3; RLF subunit beta; p102
UniProt
P25205
Swiss Prot
P25205
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human MCM3. AA range:641-690
Target
MCM3
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
89kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
89kD
Fragment
IgG
Subcellular Location
Nucleus . Chromosome . Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. .
Other Product Names
MCM3; DNA replication licensing factor MCM3; DNA polymerase alpha holoenzyme-associated protein P1; P1-MCM3; RLF subunit beta; p102
Gene ID (Human)
4172

Related Products

CatalogName
ES14996-01MCM3 (phospho-Ser112) rabbit pAb
ES6208-01MCM4 rabbit pAb
ES10749-01MCM9 rabbit pAb
ES4184-01MCM6 rabbit pAb
ES10748-01MCM8 rabbit pAb
ES4101-01MCM7 rabbit pAb
ES6207-01MCM4 (phospho Ser54) rabbit pAb
ES14999-01MCM2 (phospho-Ser139) rabbit pAb
ES4666-01RAB3IP rabbit pAb
ES20596-01WIPI2 Rabbit rabbit pAb

Alternative Products

CatalogName
NBP3-23939-100ugRabbit Monoclonal MCM3 Antibody (MCM3/8972R)
NBP3-23939-20ugRabbit Monoclonal MCM3 Antibody (MCM3/8972R)
MBS4764170-01MCM3 Rabbit mAb
E60M2955MCM3 Rabbit mAb
E2251506MCM3 Rabbit pAb
E45R12511N-100MCM3 Rabbit mAb
MBS9466720-01MCM3 Rabbit mAb
MBS9470767-01MCM3 Rabbit mAb
A11475-01MCM3 Rabbit mAb
MBS4752358-01MCM3 Rabbit mAb

Popular Products