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Prothrombin rabbit pAb

CAT: 0855-ES3856-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES3856-02Size:100 µL
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Background
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Description
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],
Product Name Alternative
F2; Prothrombin; Coagulation factor II
UniProt
P00734
Swiss Prot
P00734
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from the Internal region of human Prothrombin. AA range 420-470
Target
Prothrombin
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
70kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
70kD
Fragment
IgG
Subcellular Location
Secreted, extracellular space.
Other Product Names
F2; Prothrombin; Coagulation factor II
Gene ID (Human)
2147

UniProtKB · P00734

Prothrombin

THRB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P00734
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
F2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.5
Processing
Precursor
Secondary accessions
B2R7F7, B4E1A7, Q4QZ40, Q53H04, Q53H06, Q69EZ7, Q7Z7P3, Q9UCA1
Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Biological process

Acute phaseBlood coagulationHemostasis

Ligand

Calcium

PTM

Cleavage on pair of basic residuesDisulfide bondGamma-carboxyglutamic acidGlycoproteinZymogen

Disease

Disease variantThrombophilia

Molecular function

HydrolaseProteaseSerine protease

Domain

KringleRepeatSignal

Cellular component

Secreted

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