SV2C rabbit pAb

• Background:

  Function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles., PTM:N-glycosylated., similarity:Belongs to the major facilitator superfamily., subcellular location:Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas., subunit:Interacts with SYT1 in a calcium-dependent manner.

• Description:

  Function: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. PTM: N-glycosylated. similarity: Belongs to the major facilitator superfamily. subcellular location: Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas. subunit: Interacts with SYT1 in a calcium-dependent manner.

• UniProt:

  Q496J9

• Swiss Prot:

  Q496J9

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthesized peptide derived from the Internal region of human SV2C.

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; IHC; IF; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight:

  82kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  82kD

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas. .

• Other Product Names:

  SV2C; KIAA1054; Synaptic vesicle glycoprotein 2C

• Gene ID (Human):

  22987