FTO rabbit pAb

• Background :

  This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

• Description :

  This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011],

• UniProt :

  Q9C0B1

• Swiss Prot :

  Q9C0B1

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human FTO. AA range:19-68

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight :

  58kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  58kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Nucleus speckle . Cytoplasm . Localizes mainly in the nucleus, where it is able to demethylate N (6) -methyladenosine (m6A) and N (6),2'-O-dimethyladenosine cap (m6A (m) ) in U6 small nuclear RNA (snRNA), N (1) -methyladenine from tRNAs and internal m6A in mRNAs (PubMed:30197295) . In the cytoplasm, mediates demethylation of m6A and m6A (m) in mRNAs and N (1) -methyladenine from tRNAs (PubMed:30197295) . .

• Other Product Names :

  FTO; KIAA1752; Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein

• Gene ID (Human) :

  79068