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VDR rabbit pAb

CAT: 0855-ES3692-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES3692-02Size:100 µL
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Background
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]
Description
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011],
UniProt
P11473
Swiss Prot
P11473
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Vitamin D Receptor. AA range:181-230
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
38kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
38kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm . Localizes mainly to the nucleus (PubMed:28698609, PubMed:12145331) . Localization to the nucleus is enhanced by vitamin D3. .
Other Product Names
VDR; NR1I1; Vitamin D3 receptor; VDR; 1; 25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1
Gene ID (Human)
7421

UniProtKB · P11473

Vitamin D3 receptor

VDR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P11473
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
VDR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
VDR
EC number
—
Processing
—
Secondary accessions
B2R5Q1, G3V1V9, Q5PSV3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Disease

Disease variant

Molecular function

DNA-bindingReceptor

Ligand

Metal-bindingZinc

Biological process

TranscriptionTranscription regulation

PTM

Ubl conjugation

Domain

Zinc-finger

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