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Tropomyosin α rabbit pAb

CAT: 0855-ES3644-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by
Description
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by
Product Name Alternative
TPM1; C15orf13; TMSA; Tropomyosin alpha-1 chain; Alpha-tropomyosin; Tropomyosin-1
UniProt
P09493
Swiss Prot
P09493
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Tropomyosin alpha. AA range:40-89
Target
Tropomyosin α
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
35kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
35kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytoskeleton . Associates with F-actin stress fibers. .
Other Product Names
TPM1; C15orf13; TMSA; Tropomyosin alpha-1 chain; Alpha-tropomyosin; Tropomyosin-1
Gene ID (Human)
7168

UniProtKB · P09493

Tropomyosin alpha-1 chain

TPM1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09493
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TPM1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B7Z5T7, D9YZV2, D9YZV3, D9YZV8, P09494, P10469, Q6DV89, Q6DV90, Q7Z6L8, Q86W64, Q96IK2, Q9UCI1, Q9UCI2, Q9UCY9, Q9Y427
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Molecular function

Actin-bindingMuscle protein

Coding sequence diversity

Alternative splicing

Disease

CardiomyopathyDisease variant

Domain

Coiled coil

Cellular component

CytoplasmCytoskeleton

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