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POT1 rabbit pAb

CAT: 0855-ES3245-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES3245-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protection of telomeres 1 (POT1) Homo sapiens This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Description
Protection of telomeres 1 (POT1) Homo sapiens This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008],
Product Name Alternative
POT1; Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein
UniProt
Q9NUX5
Swiss Prot
Q9NUX5
Reactivity
Human; Monkey
Immunogen
The antiserum was produced against synthesized peptide derived from human POT1. AA range:247-296
Target
POT1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Molecular Weight
70kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
70kD
Fragment
IgG
Subcellular Location
Nucleus . Chromosome, telomere . Colocalizes with telomeric DNA.
Other Product Names
POT1; Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein
Gene ID (Human)
25913

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