POT1 rabbit pAb

• Background:

  Protection of telomeres 1 (POT1) Homo sapiens This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

• Description:

  Protection of telomeres 1 (POT1) Homo sapiens This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008],

• UniProt:

  Q9NUX5

• Swiss Prot:

  Q9NUX5

• Reactivity:

  Human; Monkey

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human POT1. AA range:247-296

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; IHC

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000; IHC-p 1:50-300

• Molecular Weight:

  70kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  70kD

• Fragment:

  IgG

• Subcellular Location:

  Nucleus . Chromosome, telomere . Colocalizes with telomeric DNA.

• Other Product Names:

  POT1; Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein

• Gene ID (Human):

  25913