PIP5KIII rabbit pAb

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CAT#:0855-ES3211-01Size:50 µL

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Background

Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns (3,5) biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKf

Description

Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns (3, 5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKf

UniProt

Q9Y2I7

Swiss Prot

Q9Y2I7

Reactivity

Human; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human PIP5K. AA range:71-120

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300

Molecular Weight

237kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

237kD

Fragment

IgG

Subcellular Location

Endosome membrane ; Peripheral membrane protein . Early endosome membrane ; Peripheral membrane protein. Cytoplasmic vesicle, phagosome membrane ; Peripheral membrane protein . Late endosome membrane ; Peripheral membrane protein . Mainly associated with membranes of the late endocytic pathway. .

Other Product Names

PIKFYVE; KIAA0981; PIP5K3; 1-phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase; FYVE finger-containing phosphoinositide kinase; PIKfyve; Phosphatidylinositol 3-phosphate 5-kinase type III; PIPkin-III; Type

Gene ID (Human)

200576

UniProtKB · Q9Y2I7

1-phosphatidylinositol 3-phosphate 5-kinase

FYV1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9Y2I7
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PIKFYVE
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: Phosphatidylinositol 3-phosphate 5-kinase
EC number: 2.7.1.150
Processing: —
Secondary accessions: Q08AR7, Q08AR8, Q53ST3, Q53T36, Q8N5H0, Q8NB67

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMetal-bindingNucleotide-bindingZinc

Disease

Corneal dystrophyDisease variant

Cellular component

Cytoplasmic vesicleEndosomeMembrane

Biological process

Host-virus interactionLipid metabolism

Molecular function

KinaseTransferase

Domain

Zinc-finger

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Alternative Products

Catalog	Name
E53P05587	PIP5KIII Rabbit Polyclonal Antibody
A101928	Anti-PIP5KIII (Rabbit, Polyclonal, IgG)
PA86589HU-01	Rabbit Anti-Human PIP5KIII Polyclonal Antibody
APRab05250-01	PIP5KIII (phospho Ser307) Rabbit Polyclonal Antibody
GTR18051826-01	PIP5KIII (phospho Ser307) rabbit pAb Antibody
P44167-01	Rabbit Polyclonal Antibody to PIP5KIII (phospho Ser307)
PA88897HU-01	Rabbit Anti-Human PIP5KIII (phospho Ser307) Polyclonal Antibody
393065	PIP5KIII discontinued
OM635694-01	PIP5KIII Antibody
ABP52212-01	PIP5KIII Polyclonal Antibody