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PIAS 1 rabbit pAb

CAT: 0855-ES3203-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES3203-01Size:50 µL
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Background
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Description
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
UniProt
O75925
Swiss Prot
O75925
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human PIAS1. AA range:10-59
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
72kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
72kD
Fragment
IgG
Subcellular Location
Nucleus speckle . Nucleus, PML body . Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton.
Other Product Names
PIAS1; DDXBP1; E3 SUMO-protein ligase PIAS1; DEAD/H box-binding protein 1; Gu-binding protein; GBP; Protein inhibitor of activated STAT protein 1; RNA helicase II-binding protein
Gene ID (Human)
8554

UniProtKB · O75925

E3 SUMO-protein ligase PIAS1

PIAS1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75925
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PIAS1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.-
Processing
—
Secondary accessions
B2RB67, B3KSY9, C5J4B4, Q147X4, Q99751, Q9UN02
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmCytoskeletonNucleus

Molecular function

DNA-bindingTransferase

Biological process

Host-virus interactionTranscriptionTranscription regulationUbl conjugation pathway

Ligand

Metal-bindingZinc

Domain

RepeatZinc-finger

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