PFK-2 car rabbit pAb

CAT: 0855-ES3182-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES3182-01Size:50 µL

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Background

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2, 6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2, 6-bisphosphate, and a fructose-2, 6-biphosphatase activity that catalyzes the degradation of fructose-2, 6-bisphosphate. This protein regulates fructose-2, 6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2, 6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

UniProt

O60825

Swiss Prot

O60825

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human PFKFB2. AA range:451-500

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Molecular Weight

58kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

58kD

Fragment

IgG

Subcellular Location

Cytosol

Other Product Names

PFKFB2; 6-phosphofructo-2-kinase/fructose-2; 6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ase 2; PFK/FBPase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme

Gene ID (Human)

5208

UniProtKB · O60825

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

F262_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O60825
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PFKFB2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: 6PF-2-K/Fru-2,6-P2ase 2, PFK/FBPase 2
EC number: —
Processing: —
Secondary accessions: O60824, Q5VVQ3, Q5VVQ4, Q9H3P1

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Molecular function

HydrolaseKinaseMultifunctional enzymeTransferase

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