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NOS2 rabbit pAb

CAT: 0855-ES2973-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2973-02Size:100 µL
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Background
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Description
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008],
UniProt
P35228
Swiss Prot
P35228
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human iNOS. AA range:117-166
Clonality
Polyclonal
Source
Rabbit
Applications
IF; WB; IHC; ELISA
Concentration
1 mg/ml
Dilution
IF: 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300
Molecular Weight
131kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
131kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytosol . Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization. .
Other Product Names
NOS2; NOS2A; Nitric oxide synthase; inducible; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2
Gene ID (Human)
4843

UniProtKB · P35228

Nitric oxide synthase, inducible

NOS2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35228
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NOS2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.14.13.39
Processing
—
Secondary accessions
A1L3U5, B7ZLY2, O60757, O94994, Q16263, Q16692, Q4TTS5, Q9UD42
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumFADFlavoproteinFMNHemeIronMetal-bindingNADPZinc

Molecular function

Calmodulin-bindingOxidoreductase

Cellular component

Cytoplasm

PTM

PhosphoproteinUbl conjugation

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