NFκB-p100 rabbit pAb

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Background

Nuclear factor kappa B subunit 2 (NFKB2) Homo sapiens This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB) . The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Description

Nuclear factor kappa B subunit 2 (NFKB2) Homo sapiens This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],

UniProt

Q00653

Swiss Prot

Q00653

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human NF-kappaB p100/p52. AA range:833-882

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IP; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Nucleus. Cytoplasm. Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B) .

Other Product Names

NFKB2; LYT10; Nuclear factor NF-kappa-B p100 subunit; DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Oncogene Lyt-10; Lyt10

Gene ID (Human)

4791

UniProtKB · Q00653

Nuclear factor NF-kappa-B p100 subunit

NFKB2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q00653
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: NFKB2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A8K9D9, D3DR83, Q04860, Q9BU75, Q9H471, Q9H472

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

ActivatorDNA-bindingRepressor

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Domain

ANK repeatRepeat

Biological process

Biological rhythmsTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Disease

Disease variantProto-oncogene

PTM

Isopeptide bondPhosphoproteinUbl conjugation

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