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Myotubularin rabbit pAb

CAT: 0855-ES2880-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2880-01Size:50 µL
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Background
This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy. [provided by RefSeq, Jul 2008]
Description
This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy. [provided by RefSeq, Jul 2008],
Product Name Alternative
MTM1; CG2; Myotubularin
UniProt
Q13496
Swiss Prot
Q13496
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Myotubularin. AA range:241-290
Target
Myotubularin
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Molecular Weight
70kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
70kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cell membrane; Peripheral membrane protein . Cell projection, filopodium . Cell projection, ruffle . Late endosome . Cytoplasm, myofibril, sarcomere . Localizes as a dense cytoplasmic network (PubMed:11001925) . Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles (PubMed:12118066) . Predominantly located in the cytoplasm following interaction with MTMR12 (PubMed:12847286) . Recruited to the late endosome following EGF stimulation (PubMed:14722070) . In skeletal muscles, co-localizes with MTMR12 in the sarcomere (By similarity) . .
Other Product Names
MTM1; CG2; Myotubularin
Gene ID (Human)
4534

UniProtKB · Q13496

Myotubularin

MTM1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13496
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MTM1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.95
Processing
—
Secondary accessions
A6NDB1, B7Z491, F2Z330, Q8NEL1
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCell projectionCytoplasmEndosomeMembrane

Disease

Disease variant

Molecular function

HydrolaseProtein phosphatase

Biological process

Lipid metabolismProtein transportTransport

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

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