MyD88 rabbit pAb

• Background:

  This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

• Description:

  This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010],

• UniProt:

  Q99836

• Swiss Prot:

  Q99836

• Reactivity:

  Human; Mouse; Rat; Pig

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human MyD88. AA range:171-220

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  IF; WB; IHC; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunocytochemistry: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight:

  33kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  33kD

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasm . Nucleus .

• Other Product Names:

  MYD88; Myeloid differentiation primary response protein MyD88

• Gene ID (Human):

  4615