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Mfn2 rabbit pAb

CAT: 0855-ES2784-01Size: 50 µLDry Ice: NoHazardous: No
CAT#: ES2784-01Size: 50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Description
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],
Product Name Alternative
MFN2; CPRP1; KIAA0214; Mitofusin-2; Transmembrane GTPase MFN2
UniProt
O95140
Swiss Prot
O95140
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Mfn2. AA range:354-403
Target
Mfn2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
86kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
86kD
Fragment
IgG
Subcellular Location
Mitochondrion outer membrane ; Multi-pass membrane protein . Colocalizes with BAX during apoptosis. .
Other Product Names
MFN2; CPRP1; KIAA0214; Mitofusin-2; Transmembrane GTPase MFN2
Gene ID (Human)
9927

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