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KIF4A rabbit pAb

CAT: 0855-ES2674-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2674-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Kinesin family member 4A (KIF4A) Homo sapiens This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]
Description
Kinesin family member 4A (KIF4A) Homo sapiens This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X. [provided by RefSeq, Mar 2010],
Product Name Alternative
KIF4A; KIF4; Chromosome-associated kinesin KIF4A; Chromokinesin-A
UniProt
O95239
Swiss Prot
O95239
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human KIF4A. AA range:1171-1220
Target
KIF4A
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Molecular Weight
140kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
140kD
Fragment
IgG
Subcellular Location
Nucleus matrix . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Midbody . Chromosome . Associates with chromosomes at all stage of mitosis (PubMed:11736643, PubMed:15297875, PubMed:15625105) . Chromatin localization is dependent on iron-sulfur cluster binding (PubMed:29848660) . In anaphase, associates with the mitotic spindle midzone (PubMed:15297875) . In telophase and cytokinesis, co-localizes with CIAO2B at the spindle midzone and midbody (PubMed:29848660, PubMed:15297875) . Co-localizes with PRC1 in early mitosis and at the spindle midzone from anaphase B to telophase (PubMed:15297875, PubMed:15625105) . Does not localize to the nucleolus (PubMed:11736643) . .
Other Product Names
KIF4A; KIF4; Chromosome-associated kinesin KIF4A; Chromokinesin-A
Gene ID (Human)
24137

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