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ACC1 antibody

CAT: 0710-FNab10685Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10685Size:100 µg
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Background
ACACA (Acetyl-CoA carboxylase 1, ACC), also named as ACAC, ACC1 and ACCA, belongs to the biotin containing enzyme family. It catalyzes the synthesis of malonyl-CoA, which is an intermediate substrate playing a pivotal role in the regulation of fatty acid metabolism and energy production. ACACA is involved in the biosynthesis of fatty acids, and malonyl-CoA produced is used as a building block to extend the chain length of fatty acids by fatty acid synthase (FAS) (PMID:19900410) . It has 4 isoforms produced by alternative promoter usage with the molecular weight between 260 kDa and 270 kDa.
Synonyms
Acetyl-CoA carboxylase 1 (ACC1) |Acetyl-Coenzyme A carboxylase alpha (ACC-alpha) |ACACA|ACAC|ACC1|ACCA
Gene ID
31
UniProt
Q13085
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Acetyl-Coenzyme A carboxylase alpha
Target
ACC1
Clonality
Monoclonal
Isotype
IgG2a
Applications
ELISA, WB, IHC
Field of Research
Cardiovascular, Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:2000-1:10000; IHC: 1:100-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
270 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
9D2
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
2223-2346aa

UniProtKB · Q13085

Acetyl-CoA carboxylase 1

ACACA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13085
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ACACA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ACC1
EC number
6.4.1.2
Processing
—
Secondary accessions
B2RP68, B2ZZ90, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Molecular function

Allosteric enzymeLigaseMultifunctional enzyme

Coding sequence diversity

Alternative promoter usage

Ligand

ATP-bindingBiotinMagnesiumManganeseMetal-bindingNucleotide-binding

Cellular component

Cytoplasm

Biological process

Fatty acid biosynthesisFatty acid metabolismLipid biosynthesisLipid metabolism

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