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Flt3-L rabbit pAb

CAT: 0855-ES2354-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2354-01Size:50 µL
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Background
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910) -positive classical DCs and their CD103 (ITGAE; MIM 604682) -positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]) .[supplied by OMIM, Jan 2011]
Description
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al. 2010 [PubMed 20933441]). [supplied by OMIM, Jan 2011],
UniProt
P49771
Swiss Prot
P49771
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Flt3 ligand. AA range:171-220
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
26kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
26kD
Fragment
IgG
Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
Other Product Names
FLT3LG; Fms-related tyrosine kinase 3 ligand; Flt3 ligand; Flt3L; SL cytokine
Gene ID (Human)
2323

UniProtKB · P49771

Fms-related tyrosine kinase 3 ligand

FLT3L_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P49771
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FLT3LG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Flt3 ligand, Flt3L
EC number
—
Processing
Precursor
Secondary accessions
A0AVC2, B9EGH2, Q05C96
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

Molecular function

Cytokine

PTM

Disulfide bondGlycoprotein

Domain

SignalTransmembraneTransmembrane helix

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