Flt3-L rabbit pAb

• Background:

  Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910) -positive classical DCs and their CD103 (ITGAE; MIM 604682) -positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]) .[supplied by OMIM, Jan 2011]

• Description:

  Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al. 2010 [PubMed 20933441]). [supplied by OMIM, Jan 2011],

• Synonyms:

  FLT3LG; Fms-related tyrosine kinase 3 ligand; Flt3 ligand; Flt3L; SL cytokine

• Gene ID:

  2323

• UniProt:

  P49771

• Cellular Locus:

  [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human Flt3 ligand. AA range:171-220

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, IHC, IF, ELISA

• Validated Applications:

  WB, IHC, IF, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight:

  26kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  26 kD

• Subcellular Location:

  [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

• Other Product Names:

  FLT3LG; Fms-related tyrosine kinase 3 ligand; Flt3 ligand; Flt3L; SL cytokine

• Gene ID (Human):

  2323

• SwissProt (Human):

  P49771