Products for Research Use Only
RegisterLogin

ERα rabbit pAb

CAT: 0855-ES2301-02Size: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES2301-02Size:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
Description
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014],
UniProt
P03372
Swiss Prot
P03372
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Estrogen Receptor-alpha. AA range:136-185
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
66kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
66kD
Fragment
IgG
Subcellular Location
[Isoform 1]: Nucleus . Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . A minor fraction is associated with the inner membrane.; [Isoform 3]: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Single-pass type I membrane protein. Associated with the inner membrane via palmitoylation (Probable) . At least a subset exists as a transmembrane protein with a N-terminal extracellular domain. .; Nucleus. Golgi apparatus. Cell membrane. Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.
Other Product Names
ESR1; ESR; NR3A1; Estrogen receptor; ER; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
Gene ID (Human)
2099

UniProtKB · P03372

Estrogen receptor

ESR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P03372
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ESR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ER
EC number
—
Processing
—
Secondary accessions
Q13511, Q14276, Q5T5H7, Q6MZQ9, Q9NU51, Q9UDZ7, Q9UIS7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

ActivatorDNA-bindingReceptor

Coding sequence diversity

Alternative promoter usageAlternative splicing

Cellular component

Cell membraneCytoplasmGolgi apparatusMembraneNucleus

Disease

Disease variantOsteoporosis

PTM

GlycoproteinLipoproteinMethylationPalmitatePhosphoproteinUbl conjugation

Ligand

Lipid-bindingMetal-bindingSteroid-bindingZinc

Biological process

TranscriptionTranscription regulation

Domain

TransmembraneZinc-finger

Related Products

CatalogName
ES1311-01ERα (phospho Ser118) rabbit pAb
ES5171-01ERα (phospho Ser167) rabbit pAb
ES20063-01ERα (Acetyl Lys266) rabbit pAb
ES20065-01ERα (Acetyl Lys303) rabbit pAb
ES5173-01ERα (phospho Ser102) rabbit pAb
ES5178-01ERβ (phospho Ser87) rabbit pAb
ES5177-01ERβ (phospho Ser105) rabbit pAb
ES5174-01ERα (phospho Ser305) rabbit pAb
ES20064-01ERα (Acetyl Lys268) rabbit pAb
ES5170-01ERα (phospho Ser106) rabbit pAb

Alternative Products

CatalogName
RTR125Rabbit-to-Rabbit Blocking Reagent
NBP1-71681Rabbit Normal Rabbit Serum
AR05252FC-NRabbit IgG Rabbit Protein
AR05110PU-NRabbit IgM Rabbit Protein
OORA00605-100MLRabbit
HY-P80879-01Rabbit IgG Isotype Control (Rabbit)
MBS9518102-01Gab1 Rabbit Rabbit Polyclonal Antibody
MBS9517836-01WIPI2 Rabbit Rabbit Polyclonal Antibody
MBS9512778-01ATM Rabbit Rabbit Polyclonal Antibody
MBS9512773-01ERK1 Rabbit Rabbit Polyclonal Antibody

Popular Products