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ERK 8 rabbit pAb

CAT: 0855-ES2300-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2300-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Catalytic activity:ATP + a protein = ADP + a phosphoprotein., domain:The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteosomal degradation., domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases., enzyme regulation:Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1., function:In vitro, phosphorylates MBP., PTM:Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme. Autophosphorylated on threonine and tyrosine residues in vitro., PTM:Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase., similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily., similarity:Contains 1 protein kinase domain., subunit:Interacts with CSK/c-Src, ABL1, RET and TGFB1I1., tissue specificity:Widely expressed with a maximal expression in lung and kidney.
Description
Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Domain: The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteosomal degradation. Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. enzyme regulation: Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1. function: In vitro, phosphorylates MBP. PTM: Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme. Autophosphorylated on threonine and tyrosine residues in vitro. PTM: Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase. similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. similarity: Contains 1 protein kinase domain. subunit: Interacts with CSK/c-Src, ABL1, RET and TGFB1I1. tissue specificity: Widely expressed with a maximal expression in lung and kidney.
Product Name Alternative
MAPK15; ERK7; ERK8; Mitogen-activated protein kinase 15; MAP kinase 15; MAPK 15; Extracellular signal-regulated kinase 7; ERK-7; Extracellular signal-regulated kinase 8; ERK-8
UniProt
Q8TD08
Swiss Prot
Q8TD08
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human MAPK15. AA range:141-190
Target
ERK8
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
60kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
60kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytoskeleton, cilium basal body . Cell junction, tight junction . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasmic vesicle, autophagosome . Golgi apparatus . Nucleus . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Co-localizes to the cytoplasm only in presence of ESRRA (PubMed:21190936) . Translocates to the nucleus upon activation (PubMed:20638370) . At prometaphase I, metaphase I (MI), anaphase I, telophase I, and metaphase II (MII) stages, is stably detected at the spindle (By similarity) . .
Other Product Names
MAPK15; ERK7; ERK8; Mitogen-activated protein kinase 15; MAP kinase 15; MAPK 15; Extracellular signal-regulated kinase 7; ERK-7; Extracellular signal-regulated kinase 8; ERK-8
Gene ID (Human)
225689

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