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ERK 5 rabbit pAb

CAT: 0855-ES20759-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20759-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5) . It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
UniProt
Q13164
Swiss Prot
Q13164
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Protein of ERK 5
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF
Dilution
WB: 1:1000-2000 IHC:1:200-500
Molecular Weight
89-115kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
89-115kD
Fragment
IgG
Subcellular Location
Cytoplasm. Nucleus. Nucleus, PML body. Translocates to the nucleus upon activation.
Other Product Names
MAPK7; BMK1; ERK5; PRKM7; Mitogen-activated protein kinase 7; MAP kinase 7; MAPK 7; Big MAP kinase 1; BMK-1; Extracellular signal-regulated kinase 5; ERK-5
Gene ID (Human)
5598

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