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ERAP1 rabbit pAb

CAT: 0855-ES2288-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2288-02Size:100 µL
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Background
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
Description
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010],
UniProt
Q9NZ08
Swiss Prot
Q9NZ08
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human ARTS-1. AA range:441-490
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
107kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
107kD
Fragment
IgG
Subcellular Location
Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
Other Product Names
ERAP1; APPILS; ARTS1; KIAA0525; Endoplasmic reticulum aminopeptidase 1; ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; Type 1 tumor necrosis facto
Gene ID (Human)
51752

UniProtKB · Q9NZ08

Endoplasmic reticulum aminopeptidase 1

ERAP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NZ08
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ERAP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.11.-
Processing
—
Secondary accessions
O60278, Q6UWY6, Q8NEL4, Q8TAD0, Q9UHF8, Q9UKY2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Adaptive immunityImmunity

Coding sequence diversity

Alternative splicing

Molecular function

AminopeptidaseHydrolaseMetalloproteaseProtease

PTM

Disulfide bondGlycoprotein

Cellular component

Endoplasmic reticulumMembrane

Ligand

Metal-bindingZinc

Domain

Signal-anchorTransmembraneTransmembrane helix

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