Products for Research Use Only
RegisterLogin

E-cadherin rabbit pAb

CAT: 0855-ES2220-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES2220-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
Description
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015],
UniProt
P12830/P19022/P22223/P55283
Swiss Prot
P12830/P19022/P22223/P55283
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Cadherin. AA range:833-882
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.
Molecular Weight
125-130kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
125-130kD
Fragment
IgG
Subcellular Location
Cell junction, adherens junction . Cell membrane ; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.
Other Product Names
CDH1; CDHE; UVO; Cadherin-1; CAM 120/80; Epithelial cadherin; E-cadherin; Uvomorulin; CD antigen CD324; CDH2; CDHN; NCAD; Cadherin-2; CDw325; Neural cadherin; N-cadherin; CD antigen CD325; CDH3; CDHP; Cadherin-3; Placental cadherin; P-cadhe
Gene ID (Human)
999/1000/1001/1002

Related Products

CatalogName
ES2219-01E-cadherin Rabbit Polyclonal Antibody
ES5578-01Cadherin-20 rabbit pAb
ES7170-01Cadherin-22 rabbit pAb
ES4408-01R-cadherin rabbit pAb
ES1826-01Cadherin-7 rabbit pAb
ES2902-01N-cadherin rabbit pAb
ES4425-01T-cadherin rabbit pAb
ES2759-01M-cadherin rabbit pAb
ES8181-01E-cadherin Rabbit Polyclonal Antibody
ES4430-01LI-cadherin rabbit pAb

Alternative Products

CatalogName
GTR18245427-01E Cadherin Rabbit mAb
APA3983-01E Cadherin Rabbit pAb
MBS8575674-01E-Cadherin Rabbit pAb
A22850E-Cadherin Rabbit mAb
A22988E-Cadherin Rabbit PolymAb®
168932Cadherin E (E-Cadherin, Cadherin-1)
GWB-AA0C6FCadherin-E/E-Cadherin, Antibody
216167Cadherin E (E-Cadherin, CDH1)
168937Cadherin E (E-Cadherin, Cadherin-1) discontinued

Popular Products