Dok-3 rabbit pAb

CAT: 0855-ES2192-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES2192-01Size:50 µL
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Domain:PTB domain mediates receptor interaction., function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL function., PTM:Constitutively tyrosine-phosphorylated., PTM:On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL kinase., similarity:Belongs to the DOK family. Type A subfamily., similarity:Contains 1 IRS-type PTB domain., similarity:Contains 1 PH domain., subunit:On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP., tissue specificity:Expressed in spleen.
Description
Domain: PTB domain mediates receptor interaction. function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL function. PTM: Constitutively tyrosine-phosphorylated. PTM: On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL kinase. similarity: Belongs to the DOK family. Type A subfamily. similarity: Contains 1 IRS-type PTB domain. similarity: Contains 1 PH domain. subunit: On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP. tissue specificity: Expressed in spleen.
UniProt
Q7L591
Swiss Prot
Q7L591
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human DOK3. AA range:101-150
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
58kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
58kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
Other Product Names
DOK3; Docking protein 3; Downstream of tyrosine kinase 3
Gene ID (Human)
79930

Popular Products