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DHRS4 rabbit pAb

CAT: 0855-ES2170-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2170-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Catalytic activity:R-CHOH-R' + NADP (+) = R-CO-R' + NADPH., function:Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones., miscellaneous:Inhibited by kaempferol, quercetin, genistein and myristic acid., similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family., subcellular location:Isoform 1 is peroxisomal, while isoform 4 is not., subunit:Homotetramer., tissue specificity:Isoform 1 is predominantly expressed in normal cervix (at protein level) . Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level) . Isoforms 5 and 6 are expressed in a few neoplastic cervical tissues.
Description
Catalytic activity: R-CHOH-R' + NADP (+) = R-CO-R' + NADPH. function: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones. miscellaneous: Inhibited by kaempferol, quercetin, genistein and myristic acid. similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. subcellular location: Isoform 1 is peroxisomal, while isoform 4 is not. subunit: Homotetramer. tissue specificity: Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoforms 5 and 6 are expressed in a few neoplastic cervical tissues.
UniProt
Q9BTZ2
Swiss Prot
Q9BTZ2
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human DHRS4. AA range:191-240
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
32-34kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
32-34kD
Fragment
IgG
Subcellular Location
[Isoform 1]: Peroxisome . Isoform 4 is not peroxisomal. .; [Isoform 7]: Nucleus .
Other Product Names
DHRS4; Dehydrogenase/reductase SDR family member 4; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; CR; PHCR; NADPH-dependent retinol dehydrogenase/reductase; NRDR; humNRDR; Peroxisomal short-chain alcohol dehydrogenase; PSCD
Gene ID (Human)
10901

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