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Cystatin 11 rabbit pAb

CAT: 0855-ES2117-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2117-01Size:50 µL
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Background
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein shown to have antimicrobial activity against E. coli. Alternative splicing yields two variants encoding distinct isoforms. [provided by RefSeq, Sep 2014]
Description
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein shown to have antimicrobial activity against E. coli. Alternative splicing yields two variants encoding distinct isoforms. [provided by RefSeq, Sep 2014],
Product Name Alternative
CST11; CST8L; Cystatin-11
UniProt
Q9H112
Swiss Prot
Q9H112
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human CST11. AA range:81-130
Target
Cystatin 11
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
17kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
17kD
Fragment
IgG
Subcellular Location
Secreted . Probably secreted into the epididymis lumen, where it localizes to the outer surface of sperm. Specifically localizes to the postacrosomal and tail regions of sperm. .
Other Product Names
CST11; CST8L; Cystatin-11
Gene ID (Human)
140880

UniProtKB · Q9H112

Cystatin-11

CST11_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9H112
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CST11
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q0VAF2, Q0VAF3, Q8WXU5, Q8WXU6, Q9H113
Protein keywords

Coding sequence diversity

Alternative splicing

Molecular function

AntibioticAntimicrobialProtease inhibitorThiol protease inhibitor

PTM

Disulfide bondGlycoprotein

Technical term

Proteomics identificationReference proteome

Cellular component

Secreted

Domain

Signal

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