CdcA3 rabbit pAb

• Background:

  Domain:The KEN box is required for the association with the APC/C-Cdh1 complex., function:F-box-like protein which is required for entry into mitosis. Acts by participating to E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase., pathway:Protein modification; protein ubiquitination., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., PTM:Ubiquitinated and degraded by the APC/C-Cdh1 complex., subunit:Interacts with SKP1A. Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

• Description:

  Domain: The KEN box is required for the association with the APC/C-Cdh1 complex. function: F-box-like protein which is required for entry into mitosis. Acts by participating to E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase. pathway: Protein modification; protein ubiquitination. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: Ubiquitinated and degraded by the APC/C-Cdh1 complex. subunit: Interacts with SKP1A. Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

• UniProt:

  Q99618

• Swiss Prot:

  Q99618

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human CDCA3. AA range:219-268

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; IHC; IF; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

• Molecular Weight:

  28kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  28kD

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasm, cytosol .

• Other Product Names:

  CDCA3; C8; GRCC8; TOME1; Cell division cycle-associated protein 3; Gene-rich cluster protein C8; Trigger of mitotic entry protein 1; TOME-1

• Gene ID (Human):

  83461