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Caspase-6 rabbit pAb

CAT: 0855-ES1855-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]
Description
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015],
Product Name Alternative
CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2
UniProt
P55212
Swiss Prot
P55212
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Caspase 6. AA range:223-272
Target
Caspase-6
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
35kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
35kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus .
Other Product Names
CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2
Gene ID (Human)
839

UniProtKB · P55212

Caspase-6

CASP6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P55212
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CASP6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CASP-6, CSP-6
EC number
3.4.22.59
Processing
Precursor
Secondary accessions
Q9BQE7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

PTM

Autocatalytic cleavageLipoproteinPalmitatePhosphoproteinZymogen

Cellular component

CytoplasmNucleus

Molecular function

HydrolaseProteaseThiol protease

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