Cleaved-Caspase-6 p18 (D179) rabbit pAb

• Background:

  This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]

• Description:

  This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015],

• Synonyms:

  CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2

• Gene ID:

  839

• UniProt:

  P55212

• Cellular Locus:

  Cytoplasm. Nucleus.

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat

• Reactivity:

  Human; Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human Caspase 6. AA range:130-179

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, IHC, IF, ELISA

• Validated Applications:

  WB, IHC, IF, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight:

  20+35kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  20+35 kD

• Subcellular Location:

  Cytoplasm . Nucleus .

• Other Product Names:

  CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2

• Gene ID (Human):

  839

• SwissProt (Human):

  P55212