BMP-8B rabbit pAb

CAT: 0855-ES1781-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES1781-01Size:50 µL
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Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]
Description
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016],
Product Name Alternative
BMP8B; BMP8; Bone morphogenetic protein 8B; BMP-8; BMP-8B; Osteogenic protein 2; OP-2
UniProt
P34820
Swiss Prot
P34820
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human BMP8B. AA range:261-310
Target
BMP-8B
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
45kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
45kD
Fragment
IgG
Subcellular Location
Secreted .
Other Product Names
BMP8B; BMP8; Bone morphogenetic protein 8B; BMP-8; BMP-8B; Osteogenic protein 2; OP-2
Gene ID (Human)
656

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