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MLK3 (phospho Ser674) rabbit pAb

CAT: 0855-ES1535-01Size: 50 µLDry Ice: NoHazardous: No
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Background
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008],
Product Name Alternative
MAP3K11; MLK3; PTK1; SPRK; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase
UniProt
Q16584
Swiss Prot
Q16584
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human MLK3 (phospho Ser674)
Target
MLK3
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Location is cell cycle dependent.
Other Product Names
MAP3K11; MLK3; PTK1; SPRK; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase
Gene ID (Human)
4296

UniProtKB · Q16584

Mitogen-activated protein kinase kinase kinase 11

M3K11_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q16584
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAP3K11
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.25
Processing
—
Secondary accessions
B4DS76, Q53H00, Q59F06, Q6P2G4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmCytoskeleton

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein

Domain

RepeatSH3 domain

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APRab05028-01MLK3 (phospho Ser674) Rabbit Polyclonal Antibody
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