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CREB-1 (phospho Ser142) rabbit pAb

CAT: 0855-ES1506-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Description
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],
Product Name Alternative
CREB1; Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1
UniProt
P16220
Swiss Prot
P16220
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human CREB around the phosphorylation site of Ser142. AA range:111-160
Target
CREB-1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
37kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
37kD
Fragment
IgG
Subcellular Location
Nucleus .
Other Product Names
CREB1; Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1
Gene ID (Human)
1385

UniProtKB · P16220

Cyclic AMP-responsive element-binding protein 1

CREB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16220
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CREB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CREB-1, cAMP-responsive element-binding protein 1
EC number
—
Processing
—
Secondary accessions
P21934, Q6V963, Q9UMA7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Biological process

Biological rhythmsDifferentiationHost-virus interactionTranscriptionTranscription regulation

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Cellular component

Nucleus

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