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ACCα (phospho Ser80) rabbit pAb

CAT: 0855-ES1467-01Size: 50 µLDry Ice: NoHazardous: No
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Background
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Description
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
UniProt
Q13085
Swiss Prot
Q13085
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Acetyl-CoA Carboxylase around the phosphorylation site of Ser80. AA range:46-95
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
280kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
280kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytosol .
Other Product Names
ACACA; ACAC; ACC1; ACCA; Acetyl-CoA carboxylase 1; ACC1; ACC-alpha
Gene ID (Human)
31

UniProtKB · Q13085

Acetyl-CoA carboxylase 1

ACACA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13085
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ACACA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ACC1
EC number
6.4.1.2
Processing
—
Secondary accessions
B2RP68, B2ZZ90, Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564, Q86WB2, Q86WB3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Molecular function

Allosteric enzymeLigaseMultifunctional enzyme

Coding sequence diversity

Alternative promoter usage

Ligand

ATP-bindingBiotinMagnesiumManganeseMetal-bindingNucleotide-binding

Cellular component

Cytoplasm

Biological process

Fatty acid biosynthesisFatty acid metabolismLipid biosynthesisLipid metabolism

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