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EGFR Mouse mAb

CAT: 0855-EM1134-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-EM1134-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades.
Description
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades.
Product Name Alternative
Epidermal Growth Factor Receptor ; ErbB-1; ErbB1; ER1; ERB-B1; MENA; HER1; Erythroblastic Leukemia Viral (v-Erb-B) oncogene Homolog, Avian; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
UniProt
P00533
Swiss Prot
P00533
Reactivity
Human
Immunogen
Synthetic Peptide
Clonality
Monoclonal
Source
Mouse
Applications
WB, IHC, IF, IP
Concentration
1mg/mL
Dilution
WB 1:1,000-3,000 IP 1:200 IF 1:100-200
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Molecular Weight
170kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
170kDa
Fragment
IgG1
Other Product Names
Epidermal Growth Factor Receptor ; ErbB-1; ErbB1; ER1; ERB-B1; MENA; HER1; Erythroblastic Leukemia Viral (v-Erb-B) oncogene Homolog, Avian; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
Gene ID (Human)
1956

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