CD5 Mouse mAb

• Background :

  CD5 is a cluster of differentiation found on a subset of IgM-secreting B cells called B-1 cells, and also on T cells. B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins.

• Description :

  CD5 is a cluster of differentiation found on a subset of IgM-secreting B cells called B-1 cells, and also on T cells. B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins.

• UniProt :

  P06127

• Swiss Prot :

  P06127

• Reactivity :

  Human, Rat, Mouse

• Immunogen :

  Synthetic Peptide

• Clonality :

  Monoclonal

• Source :

  Mouse

• Applications :

  IHC

• Concentration :

  1mg/mL

• Dilution :

  IHC 1:100-200

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Fragment :

  IgG1

• Subcellular Location :

  Membrane

• Other Product Names :

  CD5 molecule, LEU1, Lymphocyte antigen T1/Leu 1, T1

• Gene ID (Human) :

  921