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CD5 Mouse mAb

CAT: 0855-EM1071-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-EM1071-01Size:50 µL
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Background
CD5 is a cluster of differentiation found on a subset of IgM-secreting B cells called B-1 cells, and also on T cells. B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins.
Description
CD5 is a cluster of differentiation found on a subset of IgM-secreting B cells called B-1 cells, and also on T cells. B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins.
Product Name Alternative
CD5 molecule, LEU1, Lymphocyte antigen T1/Leu 1, T1
UniProt
P06127
Swiss Prot
P06127
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic Peptide
Clonality
Monoclonal
Source
Mouse
Applications
IHC
Concentration
1mg/mL
Dilution
IHC 1:100-200
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Fragment
IgG1
Subcellular Location
Membrane
Other Product Names
CD5 molecule, LEU1, Lymphocyte antigen T1/Leu 1, T1
Gene ID (Human)
921

UniProtKB · P06127

T-cell surface glycoprotein CD5

CD5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P06127
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0N0P4, A8K9I3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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