Tubulin inhibitor 42

Tubulin inhibitor 42

• CAS Number: 2135713-96-9
• UNSPSC Description: Tubulin inhibitor 42 (Compound 14b) dose-dependently inhibited the activity of β-microtubulin (IC50 = 3.5 µM).Tubulin inhibitor 42 interferes with microtubule dynamic homeostasis, resulting in the arrest of the cancer cell cycle in the G2/M phase and inducing apoptosis. Tubulin inhibitor 42 significantly inhibits the angiogenic process in vitro and in vivo, preventing vascularization and tumor growth[1].
• Target Antigen: Apoptosis; Microtubule/Tubulin
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tubulin-inhibitor-42.html
• Solubility: 10 mM in DMSO
• Smiles: OC[C@H]1[C@H](C2=CC(O)=C(C=C2)OC)N(C3=CC(OC)=C(C(OC)=C3)OC)C1=O
• Molecular Weight: 389.40
• References & Citations: [1]Zhou P, et al.Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents. Eur J Med Chem. 2018 Jan 20;144:817-842.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported