Prednisolone-d8

• UNSPSC Description:

  Prednisolone-d8 is the deuterium labeled Prednisolone. Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research[1][2].

• Target Antigen:

  Endogenous Metabolite; Glucocorticoid Receptor

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Field of Research:

  Endocrinology

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@]12[C@](CC[C@]2(O)C(CO)=O)([H])[C@@]3([2H])[C@@]([C@H](C1([2H])[2H])O)([2H])[C@@]4(C(C([2H])([2H])C3)=C([2H])C(C([2H])=C4)=O)C

• Molecular Weight:

  368.49

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Prednisolone. J Am Pharm Assoc. 1976;16(3):143-146.|[3]Musson DG, et al. Assay methodology for prednisolone, prednisolone acetate and prednisolone sodium phosphate in rabbit aqueous humor and ocular physiological solutions. J Chromatogr. 1991;565(1-2):89-102.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported