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Prednisolone-d8

CAT: 0804-HY-17463SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17463SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Prednisolone-d8 is the deuterium labeled Prednisolone. Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research[1][2].
UNSPSC
12352211
Target
Endogenous Metabolite; Glucocorticoid Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@](CC[C@]2(O)C(CO)=O)([H])[C@@]3([2H])[C@@]([C@H](C1([2H])[2H])O)([2H])[C@@]4(C(C([2H])([2H])C3)=C([2H])C(C([2H])=C4)=O)C
Molecular Formula
C21H20D8O5
Molecular Weight
368.49
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Prednisolone. J Am Pharm Assoc. 1976;16 (3) :143-146.|[3]Musson DG, et al. Assay methodology for prednisolone, prednisolone acetate and prednisolone sodium phosphate in rabbit aqueous humor and ocular physiological solutions. J Chromatogr. 1991;565 (1-2) :89-102.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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