Sheep anti Mouse Bax-beta
CAT:
579-X1290P
Size:
250 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Sheep anti Mouse Bax-beta
- Background: Bax is encoded by a 1.5 kb RNA species created by the retention of intron 5 in the bax mRNA transcript. The exon4/intron5 splice junction is evolutionarily conserved and is found in both the Human and mouse bax coding regions. The 630 bp intron 5 contributes 60 amino acids to the Bax protein before a stop codon is encountered during translation. The Bax protein is 24 kDa in size and although it contains the BH1, BH2, and BH3 domains identical to Bax, it has a unique carboxyl terminus and does not have a hydrophobic transmembrane domain (Oltvai et al., 1993). Bax mRNA has been found in many mouse tissues using RT-PCR. It is found co-expressed with Bax in lung, stomach, kidney, thymus, lymph node, bone marrow, pancreas, and spleen. Bax mRNA was very abundant in brain and duodenum with almost no Bax mRNA detected in these tissues (Oltvai et al., 1993).
- Synonyms: Apoptosis regulator Bax Cytoplasmic isoform beta , BaxB, BAX, BCL2 associated X Protein, Apoptosis regulator BAX, BCL2 associated X Protein isoform beta, Bax beta, Bax B
- UniProt: Q07812
- Host: Sheep
- Species Reactivity: Mouse
- Isotype: IgG
- Conjugation: Unconjugated
- Type: Polyclonal Antibody
- Applications: WB, IP
- Field of Research: Apoptosis
- Purification Method: Ammonium Sulfate Precipitation
- Assay Principle: Antibody detects Bax? protein by immunoprecipitation only. Will not detect denatured protein by Western blot. Optimal concentration should be evaluated by serial dilutions.
- Stability: See expiration date on vial
- Concentration: See vial for Concentration
- Form: Provided as solution in phosphate buffered saline with 0,08% sodium azide
- Precautions: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
- References & Citations: 1. Oltvai, Z.N., et al. Bcl-2 Heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993, 74, 609-619.
- Shipping Conditions: Ambient Temperature, freeze upon arrival
- Storage Conditions: Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
- Functional Analysis: WB