MX107

CAT: 0804-HY-123870Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-123870Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

MX107 is a selective and potent survivin inhibitor that suppresses triple-negative breast cancer (TNBC) cell proliferation. MX107 induces degradation of survivin and inhibitor-of-apoptosis proteins (IAPs), which inhibits nuclear factor κB (NF-κB) activation induced by DNA damage. MX107 enhances tumoricidal efficacy of genotoxic treatments synergized with chemotherapeutic drugs[1].

CAS Number

2170102-50-6

UNSPSC

12352005

Target

IAP; NF-κB; Survivin

Type

Reference compound

Related Pathways

Apoptosis; NF-κB

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mx107.html

Smiles

OC1=C2N=CC=CC2=C(COCC3=CC=C(CC)C=C3)C=C1CN4CCCC4

Molecular Formula

C24H28N2O2

Molecular Weight

376.49

References & Citations

[1]Wang W, et al. Survivin Inhibitors Mitigate Chemotherapeutic Resistance in Breast Cancer Cells by Suppressing Genotoxic Nuclear Factor-κB Activation. J Pharmacol Exp Ther. 2018 Jul;366 (1) :184-193.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

5-(((4-Ethylbenzyl)oxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol

CAS Number	2170102-50-6
PubChem CID	154730949
IUPAC Name	5-[(4-ethylphenyl)methoxymethyl]-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol
Molecular Formula	C24H28N2O2
Molecular Weight	376.5
XLogP	4.1
Topological Polar Surface Area	45.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Heavy Atom Count	28
Formal Charge	0
Complexity	460

SMILES

CCC1=CC=C(C=C1)COCC2=C3C=CC=NC3=C(C(=C2)CN4CCCC4)O

InChI

InChI=1S/C24H28N2O2/c1-2-18-7-9-19(10-8-18)16-28-17-21-14-20(15-26-12-3-4-13-26)24(27)23-22(21)6-5-11-25-23/h5-11,14,27H,2-4,12-13,15-17H2,1H3

InChIKey

HERDMVBOGPYRDY-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2170102-50-6

CID: 154730949

Formula: C24H28N2O2

MW: 376.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	376.5
XLogP3	4.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Exact Mass	376.215078140
Monoisotopic Mass	376.215078140
Topological Polar Surface Area	45.6 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	460
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-162324-01	MX106-4C

Alternative Products

Catalog	Name
MBS5812390	MX107

MX107

Chemical Information

Related Products

Alternative Products

Popular Products