Ac-Leu-Val-Lys-Aldehyde

• UNSPSC Description:

  Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II[1].

• Target Antigen:

  Cathepsin

• Type:

  Peptides

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ac-leu-val-lys-aldehyde.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)C[C@H](NC(C)=O)C(N[C@@H](C(C)C)C(N[C@H](C=O)CCCCN)=O)=O

• Molecular Weight:

  384.51

• References & Citations:

  [1]McConnell RM, et al. Inhibition studies of some serine and thiol proteinases by new leupeptin analogues. J Med Chem. 1993 Apr 16;36(8):1084-9.|[2]Wang YR, et al. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. PLoS One. 2013 Sep 20;8(9):e75702.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  147600-40-6