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Fingolimod (Standard)

CAT: 0804-HY-11063R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-11063R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fingolimod (Standard) is the analytical standard of Fingolimod. This product is intended for research and analytical applications. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1].
CAS Number
162359-55-9
Product Name Alternative
FTY720 free base (Standard)
UNSPSC
12352005
Target
LPL Receptor; PAK; Reference Standards
Type
Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; Others
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fingolimod-standard.html
Purity
99.97
Smiles
OCC(CCC1=CC=C(CCCCCCCC)C=C1)(N)CO
Molecular Formula
C19H33NO2
Molecular Weight
307.47
References & Citations
[1]Rolin J, et al. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer Immunol Immunother. 2010, 59 (4), 575-586.|[2]Szepanowski F, et al. Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling. J Neuroinflammation. 2016 Jun 10;13 (1) :143.|[3]Airas L, et al. In vivo PET imaging demonstrates diminished microglial activation after fingolimod treatment in an animal model of multiple sclerosis. J Nucl Med. 2015 Feb;56 (2) :305-10.|[4]Shirakabe K, et al. Modification of lymphocyte migration to Peyer's patches by inhibition of sphingosine-1-phosphate lyase ameliorates murine colitis. J Gastroenterol Hepatol. 2018 Jan 15.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

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