Fingolimod (hydrochloride) (Standard)

• Product Name Alternative:

  FTY720 (Standard)

• UNSPSC Description:

  Fingolimod (hydrochloride) (Standard) is the analytical standard of Fingolimod (hydrochloride). This product is intended for research and analytical applications. Fingolimod hydrochloride (FTY720), an analog of sphingosine, is a potent sphingosine 1-phosphate (S1P) receptors modulator. Fingolimod hydrochloride is phosphorylated by sphingosine kinases, particularly by SK2, and then binds S1PR1, 3, 4, and 5. Fingolimod hydrochloride induces the internalization of S1P1, and consequently, inhibits S1P activity. Fingolimod hydrochloride also is a pak1 activator[1][4].

• Target Antigen:

  LPL Receptor; PAK

• Type:

  Reference Standards

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton;GPCR/G Protein

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/fingolimod-hydrochloride-standard.html

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  OCC(N)(CO)CCC1=CC=C(C=C1)CCCCCCCC.[H]Cl

• Molecular Weight:

  343.93

• References & Citations:

  [1]Rolin J, et al. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer Immunol Immunother. 2010, 59(4), 575-586.|[2]Coldewey SM, et al. Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Sci Rep. 2016 Jun 9;6:27594.|[3]Cipriani R, et al. FTY720 attenuates excitotoxicity and neuroinflammation. J Neuroinflammation. 2015 May 8;12:86.|[4]Arielle M Bryan, et al. Sphingosine-1-phosphate receptors and innate immunity. Cell Microbiol. 2018 May;20(5):e12836.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  162359-56-0