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Glabrone

CAT: 0804-HY-N4194-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N4194-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA) . Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity[1][2][3].
CAS Number
60008-02-8
UNSPSC
12352005
Target
Influenza Virus; PPAR
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/glabrone.html
Purity
99.08
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1C(C2=CC=C3C(C=CC(C)(C)O3)=C2O)=COC4=CC(O)=CC=C14
Molecular Formula
C20H16O5
Molecular Weight
336.34
References & Citations
[1]Grienke U, et al. Computer-guided approach to access the anti-influenza activity of licorice constituents. J Nat Prod. 2014 Mar 28;77 (3) :563-70.|[2]Kuroda M, et al. Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity. Bioorg Med Chem. 2010 Jan 15;18 (2) :962-70.|[3]Kuang Y, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin. Eur J Pharm Sci. 2021 Jun 1;161:105786.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PPARγ

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